Rapid synthesis of oligodeoxyribonucleotides on a grafted polymer support

Rapid synthesis of oligodeoxyribonucleotides on a grafted polymer support.

Rapid synthesis of oligodeoxyribonucleotides is described by a solid phase method. Polysterene grafted on the surface of polytetrafluoroethylene has been found to be an adequate support. The properties of the support were studied in the synthesis of a number of oligonucleotides 6 to 15 nucleotides long. A flow-type semi-automatic synthesizer has been used. Each nucleotide addition involves seve...

Synthesis of oligodeoxyribonucleotides on silica gel support.

A rapid solid phase method of oligonucleotide synthesis based on monomeric protected nucleosides has been developed.

Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates.

A phosphotriester solid phase method on a polyamide support has been used to prepare oligodeoxyribonucleotides up to 12 units long. Compared to solid phase phosphodiester synthesis the new methodology is quicker, more flexible and gives 10-60-fold better overall yields.

Environmentally Friendly Synthesis of Polymer-Grafted Nanoparticles

Enzymatic synthesis of organic-polymer-grafted DNA.

To create bioorganic hybrid materials, interdisciplinary work in the fields of chemistry, biology and materials science is conducted. DNA block copolymers are promising hybrid materials due to the combination of properties intrinsic to both the polymer and the nucleic acid blocks. Until now, the coupling of DNA and organic polymers has been exercised post-synthetically in solution or on solid s...